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This article was originally published on January 30, 2023, and updated on August 6, 2025. Liquefied gases, such as nitrogen, oxygen and helium, are used in many cryogenic applications. These systems operate at extremely low temperatures, typically below -150 °F, and introduce a unique set of pressure measurement challenges. Instruments exposed to these conditions must withstand intense thermal stress, potential material brittleness and design limitations due to space constraints. At Ashcroft, we understand the implications of these conditions and know how to take precautions to prepare for potential pressure gauge failure. Our pressure measurement expertise relating to industrial systems, including cryogenic applications, helps ensure reliable performance, process safety and long-term instrument protection. Read this article to learn more about cryogenics, how to measure pressure in these applications, and how to protect your instruments from the effects of very low temperatures.